In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus · HackerPapers discussions

In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus — mentioned by esja

Tue, 05 Jan 2021 12:14:57 GMT

Can you explain how that evolutionary path led to the virus becoming better adapted to humans than it is to bats, and can you explain how all the samples we have ever found, from the very beginning of this outbreak, are uniquely adapted to humans? https://arxiv.org/abs/2005.06199

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In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus — mentioned by esja

Tue, 05 Jan 2021 12:07:49 GMT

Can you explain how this virus became (instantly) better adapted to humans than it is to bats? https://arxiv.org/abs/2005.06199

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In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus — mentioned by esja

Tue, 05 Jan 2021 12:06:33 GMT

Then can you explain how this virus became (instantly) better adapted to humans than it is to bats? https://arxiv.org/abs/2005.06199

Paper and discussion history. A mention is not an endorsement.

In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus — mentioned by inciampati

Sun, 05 Jul 2020 16:16:56 GMT

Sure, here you go: https://arxiv.org/abs/2005.06199 This uses a rigorous bioinformatic analysis to demonstrate that the SARS-CoV-2 spike protein has dramatically stronger binding affinity for human ACE2 than any other known version of the protein. This is the case for the version of the protein observed at the very beginning of the outbreak. The virus evolves slowly, so this implies a very long period of transmission in human cells, which is compatible with a zoonotic transfer much earlier than expected (possibly many years) or gain of function experiments in cell cultures. As a biologist, I…

Paper and discussion history. A mention is not an endorsement.