On the genetic architecture of intelligence and other quantitative traits · HackerPapers discussions

On the genetic architecture of intelligence and other quantitative traits — mentioned by noch

Thu, 30 Jul 2020 00:50:27 GMT

The article you linked to is helpful but makes several important claims/conclusions that have been convincingly disproved/challenged in the time since 1996. For instance, it claims: > In fact IQ is a great example of a trait that is highly heritable but not genetically determined [...] However, "On the genetic architecture of intelligence and other quantitative traits" (Hsu, 2014, https://arxiv.org/abs/1408.3421) which cites a substantial amount of supporting research, notes: "The largest component of genetic variance for both height and intelligence is additive(linear), leading to important…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by wycs

Mon, 26 Nov 2018 06:25:57 GMT

No. I think the claim "one can raise IQ several standard deviations by editing <200 alleles" is likely true:https://arxiv.org/pdf/1408.3421.pdf

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On the genetic architecture of intelligence and other quantitative traits — mentioned by gwern

Thu, 27 Jul 2017 19:38:56 GMT

Well, it wasn't wrong, necessarily. A large project in 2013 to start uncovering the genetics of intelligence did in fact finally succeed and end the debate over the heritability of intelligence once and for all. It just wasn't BGI's project... Hsu has acknowledged that it didn't work out, but BGI's primarily organizational failure, and intelligence/genetics research since then IMO, doesn't undermine any of his broader claims as expressed in https://arxiv.org/abs/1408.3421 but supports them - intelligence is definitely highly heritable and reasonably close to the classic twin estimates, mostly…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by defen

Tue, 23 May 2017 23:43:34 GMT

> But not a straight linear additive effect. It mostly is when you're talking about "why person X has a higher IQ than person Y". It's not when you're asking why or how humans have intelligence at all, obviously. https://arxiv.org/abs/1408.3421

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On the genetic architecture of intelligence and other quantitative traits — mentioned by rlanday

Tue, 23 May 2017 01:36:15 GMT

There's reason to believe that the combined effect from all these different gene variants is approximately linear. Effects caused by multiple variants interacting are difficult for natural selection to operate on because of the way sexual reproduction works. See section 3.1 of this paper, "On the genetic architecture of intelligence and other quantitative traits": https://arxiv.org/abs/1408.3421

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On the genetic architecture of intelligence and other quantitative traits — HN submission

Sun, 05 Mar 2017 12:41:29 GMT

On the genetic architecture of intelligence and other quantitative traits

3 points; 0 discussion replies on HN. Paper and source history. A submission is not an endorsement.

On the genetic architecture of intelligence and other quantitative traits — mentioned by Moshe_Silnorin

Sun, 05 Mar 2017 00:40:09 GMT

I agree with this, but not a popular opinion. Hence the down votes you are getting. Korea and China don't have the same memetic immune response to such ideas, injecting one's children with growth hormone in hope of increasing future job prospects, for example, is extremely common in Korea. I suspect embryo selection and generic engineering for increased IQ will take off in East Asia first. Then we will be forced to allow it to compete. 50+ more IQ points looks very possible: https://arxiv.org/abs/1408.3421 However, any significant lag could spell the end of American economic dominance. For…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by dalke

Wed, 06 Apr 2016 09:34:49 GMT

This appears to be a blog argument with little relevance to HN. I'll summarize it as: Physicist Hsu argues that there are techniques by which it may be possible to genetically engineer hyper-intelligent humans. Biologist Myers argues that it's hard to measure intelligence, it's not clear that intelligence can easily be tweaked through the genes, and other biological complications, as well as questions about ethics and the observation that better "sociology and education and social services" is already known to lead to more intelligent people, so why not focus on that instead of "mad…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by Moshe_Silnorin

Mon, 21 Mar 2016 01:05:06 GMT

Empirically, on average they do better. There are brilliant losers. But brilliant people, on average, are wealthier and have higher status than less-brilliant people. Also, I suspect conscientiousness (another big factor in success) has a significant heritable component. >If you want to improve population intelligence, it may be better to invest in better nutrition, health care, and education. We've already plucked this fruit. Genetic engineering of embryos to IQs higher than any living human looks possible without side effects, as alleles that effect intelligence aren't likely to be…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by galtonsieve

Tue, 08 Dec 2015 13:32:36 GMT

The N. vs S. Korean example you mention is explicitly discussed in one of Hsu's articles. (Secular change in height due to improved environmental conditions.) http://arxiv.org/abs/1408.3421 Section 2.3: "Let me reiterate that within a range of favorable environments (i.e., providing good nutrition, hygiene, and access to education), evidence strongly supports the claim that individual differences in cognitive ability are largely associated with genetic differences. Figure 8. Increase in stature in European countries over time, almost +2 SD. Nutrition, hygiene, and average number of years of…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by Moshe_Silnorin

Mon, 16 Nov 2015 15:47:03 GMT

I'm getting this from Hsu. He seems to think this will not be an issue: http://arxiv.org/abs/1408.3421

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On the genetic architecture of intelligence and other quantitative traits — HN submission

Sun, 26 Oct 2014 21:02:57 GMT

On the genetic architecture of intelligence and other quantitative traits

2 points; 0 discussion replies on HN. Paper and source history. A submission is not an endorsement.

On the genetic architecture of intelligence and other quantitative traits — HN submission

Fri, 17 Oct 2014 02:38:33 GMT

On the genetic architecture of intelligence and other quantitative traits [pdf]

3 points; 1 discussion reply on HN. Paper and source history. A submission is not an endorsement.

On the genetic architecture of intelligence and other quantitative traits — mentioned by stephenhsu

Thu, 16 Oct 2014 17:04:28 GMT

I just realized I've said all of this already in http://arxiv.org/pdf/1408.3421v2.pdf (p.16): ... The preceding discussion is not intended to convey an overly simplistic view of genetics or systems biology. Complex nonlinear genetic systems certainly exist and are realized in every organism. However, quantitative differences between individuals within a species may be largely due to independent linear effects of specific genetic variants. As noted, linear effects are the most readily evolvable in response to selection, whereas nonlinear gadgets are more likely to be fragile to small changes.…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by stephenhsu

Thu, 16 Oct 2014 16:30:49 GMT

The question of additivity of genetic effects is discussed in more detail in reference [1] above (sections 3.1 and also 4): http://arxiv.org/pdf/1408.3421v2.pdf In plant and animal genetics it is well established that the majority of phenotype variance in complex traits which is under genetic control is additive. (Linear models work well in species ranging from corn to cows; cattle breeding is now done using SNP genotypes and linear models to estimate phenotypes.) There are also direct estimates of the additive / non-additive components of variance for human height and IQ, from twin and…

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On the genetic architecture of intelligence and other quantitative traits — mentioned by tucosan

Thu, 16 Oct 2014 15:41:41 GMT

The author of that piece on Nautilus also published a paper on the topic: http://arxiv.org/abs/1408.3421

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